The present findings demonstrate that in response to a 4-wk exercise intervention combining HII and continuous exercise (1) gastric emptying, glucose, insulin, ghrelin, appetite ratings and non-exercise activity are unaltered despite an increase in ad libitum test meal energy intake; and (2) body composition, cardiorespiratory fitness and blood pressure are improved, in men with overweight and obesity. Here, GHRL is linked to obesity due to melanocortin 4 receptor deficiency.