Multivariable Cox regression analysis revealed that a consistent BP elevation in the wintertime in CKD patients with home BP monitoring was significantly associated with a worse outcome after adjustment for age, gender and smoking as well as adjustment for age, gender, smoking, heart failure, diabetic nephropathy, eGFR, albumin, hemoglobin, urine PCR, and ACEIs/ARBs (HR: 2.09, 95% CI: 1.37–3.20, P = 0.0007; HR: 1.72, 95% CI: 1.09–2.72, P = 0.0205, respectively) (Table 7). The gene discussed is ALB; the disease is chronic kidney disease.