IMPDH2 and breast adenocarcinoma: For example, in MCF7 human breast adenocarcinoma cell line, inhibition of IMPDH activity by treatment with mycophenolic acid (MPA), the non-competitive inhibitor of IMPDH, induces the aggregation of IMPDH2 into the rod- and ring- shaped marcrostructure, the first report on the formation of IMPDH2 cytoophidium (Ji et al., 2006).