CXCL8 and neoplasm: For instance, CXCR2 and CXCL8 are overexpressed in various human cancers, such as oesophageal cancer, pancreatic cancer and ovarian cancer, and this overexpression positively correlates with aggressive tumor behavior and poor prognosis (Wente et al., 2006; Waugh and Wilson, 2008; Nishi et al., 2015; Ignacio et al., 2018).