To explore the effect of CXCL8-CXCR2 signaling in nasopharyngeal carcinoma, we performed immunohistochemistry staining for CXCR2 and CXCL8 in an NPC tissue microarray and found CXCR2 localized in both tumor cells and stromal cells; CXCL8 was frequently observed in the cytosol of tumor cells (Figure 1A and Supplementary Table). Here, CXCR2 is linked to neoplasm.