CXCL8 and neoplasm: Additionally, the CXCL8-CXCR2 pathway is associated with angiogenesis and tumor-stromal interactions, where it promotes tumor progression and metastasis (Wang et al., 2006; Waugh and Wilson, 2008; Singh et al., 2009; Ijichi et al., 2011; Lee Y.S. et al., 2012; Steele et al., 2016).