The Nck2 gene localizes to chromosome 2 band q12 (2q12) in a region linked to neurological development (Chen et al., 1998; Griggs et al., 2009; Hladilkova et al., 2015), and GWAS analysis link Nck2 SNPs to drug addiction, Alzheimer’s Disease, and platelet levels (Liu et al., 2013; Chen M. H. et al., 2020; Schwartzentruber et al., 2021). This evidence concerns the gene NCK2 and early-onset autosomal dominant Alzheimer disease.