The Nck1 gene localizes to chromosome 3q21 in a region mutated in various cancers (Chen et al., 1998), and genome-wide association studies (GWAS) link Nck1 single nucleotide polymorphisms (SNPs) with obesity, dyslipidemia, circulating leukocyte counts, platelet counts, and coronary artery disease (Locke et al., 2015; van der Harst and Verweij, 2018; Chen M. H. et al., 2020). The gene discussed is NCK1; the disease is obesity due to melanocortin 4 receptor deficiency.