IL6 and hematopoietic and lymphoid cell neoplasm: A number of studies have shown IL-6 and its major effector STAT3 as pro-tumorigenic mediators in many cancers, including melanoma, breast, lung, colon, prostate, ovarian, and hematological cancers, and to be associated with OB–OC coupling via notch signaling (Sethi et al., 2011).