A number of studies have shown IL-6 and its major effector STAT3 as pro-tumorigenic mediators in many cancers, including melanoma, breast, lung, colon, prostate, ovarian, and hematological cancers, and to be associated with OB–OC coupling via notch signaling (Sethi et al., 2011). The gene discussed is STAT3; the disease is hematopoietic and lymphoid cell neoplasm.