Most of them, such as the breast carcinoma cell lines MDA-MB-231 and MCF7, can directly promote differentiation of hOC (Figure 1A), whereas only MCF7 can induce a slight increase in OC activity (type I collagen degradation, Figure 1B) at in vitro standard culture condition and under physiological pH 7.4. The gene discussed is BGLAP; the disease is breast carcinoma.