Recent studies have developed two FTO inhibitors, FB23 and FB23-2, they have been shown to promote differentiation/apoptosis of acute myeloid leukemia cell lines in vitro, and significantly inhibit the proliferation of human acute myeloid leukemia (AML) cell lines and primary AML cells, and the progression of human acute myeloid leukemia in xenografted mice (Huang et al., 2019). Here, FTO is linked to acute myeloid leukemia.