As presented in Figure 8, we found that GNAQ (Figure 8B), SCP2 (Figure 8C), RGS5 (Figure 8D), ATP1B1 (Figure 8F), SLC25A20 (Figure 8G), HADHA (Figure 8H), HSDL2 (Figure 8I), and ACOX1 (Figure 8J) were suppressed in ESCC samples compared to EA samples; however, MAPK1 (Figure 8E) and NLN (Figure 8K) were suppressed in ESCC samples compared to EA samples. This evidence concerns the gene MAPK1 and esophageal squamous cell carcinoma.