Moreover, we found that GNAQ, RGS5, ATP1B1, HADHA, HSDL2, SLC25A20, ACOX1, and SCP2 were reduced in ESCC samples compared to EA samples; however, MAPK1 and NLN were reduced in ESCC samples compared to EA samples. Here, GNAQ is linked to esophageal squamous cell carcinoma.