To date, CGRP has been applied in the treatment of several diseases, such as migraine, diabetes, and liver damage, as well as for cardioprotection (Kroeger et al., 2009; Yuan et al., 2017; Guo et al., 2018, 2020), suggesting that CGRP can be used safely and effectively in the treatment of age-related osteoporosis. Here, CALCA is linked to migraine disorder.