EIF2AK3 and Alzheimer disease: The coalescence of upregulated chaperones, phosphorylated PERK-eIF2A-CHOP proteins chaperones and the build-up of ubiquitinated proteins are the salient features of ER stressed condition in AD (Van Leeuwen et al., 1998; Stutzbach et al., 2014; Duran-Aniotz et al., 2017).