DDIT3 and Disorder of lipid metabolism: Knock down of CHOP alleviates ER stress and mitigates lipid metabolic disorders in atherosclerotic conditions, hence signifies CHOP as a potential therapaeutic target (Sun et al., 2018; Zahid et al., 2020) the UPR and ER stress response arms for therapy has burgeoned in the recent past, however, successful clinical trials are lacking as many of these targets do not directly target any upstream ER regulatory checkpoints (Subach et al., 2009; Ren et al., 2021).