Overexpression of native α-syn inhibits exocytosis (Logan et al., 2017) and mutations in the SNCA gene that encodes native α-syn are associated with PD with autosomal dominant inheritance pattern with a relatively early onset age than sporadic PD patients (Polymeropoulos et al., 1996; Ikeuchi et al., 2008). The gene discussed is SNCA; the disease is Parkinson disease.