Comparison of PLXDC2 expression level in different samples (metaplasia, normal, PBMC, and tumor) was established, and the result showed that PLXDC2 scarcely express in the normal sample, while upregulating in PBMC and tumor samples in both macrophages and fibroblasts, and metaplasia in macrophages (Figures 6E,F). The gene discussed is PLXDC2; the disease is neoplasm.