This study provides evidence that let-7d-5p transferred from exosomes derived from non-small cell lung cancer cells promotes the development of CIBP by targeting OPRM1, but further studies are needed both preclinically and clinically to develop a new potential therapy, which can alleviate CIBP effectively, and increase the functional status and quality of life of CIBP patients. The gene discussed is OPRM1; the disease is non-small cell lung carcinoma.