Within the signature, solute carrier family 26 member 11 (SLC26A11), tripartite motif-containing 67 (TRIM67), and aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) were downregulated in TP53-mutated PC and positively correlated with each other, while the expressions of urothelial carcinoma-associated 1 (UCA1) and long intergenic non-protein-coding RNA 1559 (LINC01559) were upregulated and positively correlated with each other (p < 0.05; Figures 2F–K and Supplementary Table 2). The gene discussed is TRIM67; the disease is pachyonychia congenita.