Mutated in a wide range of cancer types and in over 70% of PC (Waddell et al., 2015; Kastenhuber and Lowe, 2017), tumor suppressor TP53 played a pivotal role in cellular stress response and acted as a tumor suppressor gene in PC (Kruiswijk et al., 2015; Kleeff et al., 2016). The gene discussed is TP53; the disease is pachyonychia congenita.