For example, LINC01559 could facilitate pancreatic tumor proliferation and migration through the regulation of Rubisco accumulation factor (RAF)1 overexpression and Yes-associated protein (YAP)-mediated pathway (Chen et al., 2020; Lou et al., 2020); located at the hub of transcription factor network, ARNT2 functions as a key component of oncogenic signature, contributing to cancer cell aggressiveness (Bogeas et al., 2018). The gene discussed is ARNT2; the disease is cancer.