Zhang X. et al. (2020) showed that FOXCUT promotes the metastasis and proliferation of colorectal cancer by activating the forkhead box C1/PI3K/Akt pathway. In addition, FOXCUT plays important roles in the molecular mechanisms of breast cancer, nasopharyngeal carcinoma, gastric adenocarcinoma, and esophageal squamous cell carcinoma, and can be used as a prognostic biomarker of esophageal squamous cell carcinoma (Pan et al., 2014; Liu et al., 2015; Xu et al., 2017; Zhao and Shen, 2019). Here, AKT1 is linked to colorectal cancer.