In a mouse model of antibody-mediated arthritis induced by transfer of K/BxN mouse serum, Notch3-deficient mice were resistant to arthritis induction and anti-Notch3 neutralizing antibodies blunted disease severity (with lesser effects for anti-Notch1 antibodies) (Wei et al., 2020). The gene discussed is NOTCH3; the disease is arthritic joint disease.