Interestingly, GA alterations are also a hallmark of common forms of adult neurodegenerative processes (Rabouille and Haase, 2016), and cancers (Petrosyan, 2015) and ARF-mediated ER–GA trafficking perturbation were demonstrated in amyotrophic lateral sclerosis (ALS) (Zhai et al., 2015; Atkin et al., 2017). Here, CDKN2A is linked to amyotrophic lateral sclerosis.