Moreover, experimental evidence shows a fundamental role also of RHOA in cell-type specification of developing brains (Dupraz et al., 2019) and neurite outgrowth (Kouchi et al., 2011; Tan et al., 2020), and this protein was recently involved in a newly discovered syndrome, the “RHOA-related mosaic ectodermal dysplasia,” with clear signs of leukoencephalopathy and anomalies in NC derivatives (Vabres et al., 2019). Here, RHOA is linked to ectodermal dysplasia syndrome.