NFE2L2 and liver dysplastic nodule: Nrf2 modulators, including maxacalcitol (an active vitamin D analog), sulforaphane, chlorogenic acid (CGA), epigallocatechin gallate, and sitagliptin, exert a protective effect on DN by suppressing oxidative stress (Cui et al., 2012; Nakai et al., 2014; Civantos et al., 2017; Sun et al., 2017; Bao et al., 2018).