Recent studies have proved that PARP1 inhibition can protect diabetic heart via activating SIRT1-PGC1 alpha axis (Waldman et al., 2018); Through activating SIRT1-induced inhibition of PARP1, post myocardial infarction infammation and cardiac remodeling can be prevented (Eid et al., 2020). This evidence concerns the gene SIRT1 and myocardial infarction.