It has been reported that Sp1 is closely related to cancers, and high level of Sp1 in human blood is perceived as a negative prognostic factor to cancers (Mertens-Talcott et al., 2007; Chadalapaka et al., 2008, 2013; Chintharlapalli et al., 2009, 2011; Papineni et al., 2009; Colon et al., 2011). This evidence concerns the gene SP1 and cancer.