TNF and neoplasm: In particular, we have shown that a cyclic CGisoDGRG peptide (called iso1) coupled to human serum albumin (iso1-HSA) can be used for the functionalization of nanogold bearing TNF or interleukin-12 (IL12), to enable “active” targeted delivery of nanoparticles to the tumor vasculature (Curnis et al., 2013; Gasparri et al., 2019).