EIF2AK3 and Wolcott-Rallison syndrome: Wolcott–Rallison syndrome (WRS, OMIM: 226980) is caused by an autosomal eukaryotic translation initiation factor 2-a kinase 3 (EIF2AK3) deficiency, associated with permanent diabetes and skeletal dysplasia in newborn period or early infancy, hepatic dysfunction, and growth retardation, which was first reported in 1972 by Wolcott and Rallison (1–3).