HOTAIR inhibits miR-7 in CSCs of MCF-7 and MDA-MB-231 breast cancer cell lines and thus promote the overexpression of SETDB1, STAT3, c-Myc, twist, and miR-9 (46) and repression of E-cadherin (46, 68) to the benefit of the EMT process. The gene discussed is STAT3; the disease is breast carcinoma.