GSDME and neoplasm: Pyroptosis is mainly divided into the classical pathway, which depends on caspase-1 (cysteine aspartase-1) to mediate pyroptosis, the nonclassical pathway, which depends on caspase-4/5/11 to induce pyroptosis, and a pathway by which activation of tumor drugs induces caspase-3-mediated cleavage of GSDME into GSDME-N, which leads to pyroptosis.