TNF and pancreatic neoplasm: In addition, tumor cells product pro-cachectic factors such as proteolysis-inducing factor (34) and also interact with host cells to produce inflammatory cytokines, such as TNF-α, IL-1, and IL-6 which activate muscular nuclear factor-kappa β (NF-κβ) and cause wasting of skeletal muscle (35, 36) notably in pancreatic cancer (37).