ADIPOQ and Insulin resistance: In addition, the available data suggest a potential anti-tumor effect of the practice of physical activity and a benefit on survival, which could be mediated in particular by the decrease in insulin resistance, the modulation of the secretion of adiponectins, the decrease of the inflammatory syndrome, a modulating effect of intratumoral signaling pathways, a decrease in the toxicity of the treatments and therefore a better dose-intensity, and the reduction of sarcopenia (46–48).