Then, we also observed that ALA treatment not only enhanced NRF2 and p-NRF2 levels (Figure 5D) but also increased metastasis-associated proteins including MMP-2, MMP-9, and VEGF levels in lung and liver metastasis tissues (Figure 5E), indicating that NRF2 activation can promote BC metastasis by increasing metastasis-associated genes. This evidence concerns the gene MMP9 and breast cancer.