Furthermore, IP-10 was the most abundant CXCR3 ligand in the ex vivo metastatic liver MPS (Figure 1A), stage IV patients (Figure 1B) as well as the study by Chen et al. (25), Additional analysis of data by Curtis et al. (31), and Rueda et al. (32), found IP-10 to be increased significantly with increasing tumor grade (Supplementary Figure 2A). This evidence concerns the gene CXCL10 and neoplasm.