More than 60% of MNs are disrupted, and then, damaged DNA is released (6, 39) However, in our investigation, as well as a previous report (18), MNs formed in a variety of cancer cell lines, including breast, colorectal, cervical and kidney cancer cell lines, generally had intact nuclear lamina proteins, such as Lamin A/C or B or their receptor LBR, nuclear pore complex Nup153), TPR blanked protein), and integral membrane proteins Sun2, nesprin2) (40). Here, SYNE2 is linked to cancer.