FOXO3 and neoplasm: The subfamily of FOXO transcription factors, including FOXO1 (also known as forkhead in rhabdomyosarcoma), FOXO3 (also known as forkhead in rhabdomyosarcoma-like 1), FOXO4, and FOXO6, is widely expressed in cells and integrates a variety of growth factors, oxidative stress signals, and other stimulatory signals, thereby inducing the specific expression of downstream signaling molecules and regulating the cell cycle, senescence, apoptosis, oxidative stress, stem cell differentiation, and tumor occurrence and development (8, 9).