FOXO3 and neoplasm: In human epidermal growth factor receptor (HER)-2+ tumor cells with an overactivated PI3K/AKT signaling pathway, the activity of FOXO3 was promoted by AKT inhibitors, resulting in increased expression of tyrosine kinase receptors, such as HER3, IGF-1, and insulin receptors, as well as enhanced cell aggressiveness (62).