CDKN1B and Hepatic fibrosis: (124) revealed that ROS from NOX1/NADPH oxidase can oxidize and inactivate PTEN, thereby positively regulating the AKT/FOXO4/P27(kip1) signaling pathway, promoting hematopoietic stem cell proliferation following liver injury induced by bile duct ligation and accelerating the development of liver fibrosis.