Higher expression of METTL18 in HCC is positively related to T stage (OR = 1.06 for T2, T3 and T4 vs. T1), pathologic stage (OR = 1.05 for Stages II−IV vs. Stage I), histological grade (OR = 1.08 for G3 and G4 vs. G1 and G2), adjacent hepatic tissue inflammation (OR = 1.06 for Mild and Severe vs. None), vascular invasion (OR = 1.05 for yes vs. no), race (OR = 1.07 for Asian and Black vs. White), and AFP (ng/ml) (OR= 1.04 for >400 vs. <=400) (all P < 0.05). This evidence concerns the gene METTL18 and hepatocellular carcinoma.