Recently, Fridlander found that compared with the mice without SM 16, after blocking the TGF-β signaling pathway with SM 16, the administration group increased the number of TANs in the tumor, slowed down the tumor growth, induced the activation of anti-tumor effect of CD8+ T cells, and induced the aggregation of Neutrophils (40). The gene discussed is TGFB1; the disease is neoplasm.