VEGF/VEGFR2 is a major signaling axis driving tumor angiogenesis, and blockade of this pathway induces upregulation of VEGF-independent compensatory pro-angiogenic factors, including fibroblast growth factor (FGF) 2, platelet-derived growth factor, and angiopoietin-1 and 2 (31). This evidence concerns the gene VEGFA and neoplasm.