Many inhibitory mechanisms are active within tumor microenvironment, such as lack of MHC molecules in tumors, increased inhibitory signals (PD-1/PD-L1, Tim-3/phospholipids, BTLA, LAG3, IDO, Arginase), Tregs, myeloid-derived suppressor cells, M2 macrophages and hypoxia. This evidence concerns the gene CD274 and neoplasm.