Except for ALOX15B and SLC44A4, all of the genes included in our NEST model have previously been associated with leukemia [FGF13 (53) and DNTT (54)] or other cancer types [C1orf116 (55), FRMD6 (56), TFCP2L1 (57), ITPR3 (58), and PCOLCE2 (59)]. The gene discussed is TFCP2L1; the disease is cancer.