EGFR and non-small cell lung carcinoma: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is currently recommended as a standard first-line therapy for advanced non-small cell lung cancer (NSCLC) patients harboring active EGFR mutations, which was reported to prolong progression-free survival (PFS) compared with standard platinum-based chemotherapy significantly (1–3).