For example, in breast cancer, the lncRNA NKILA induced by the NF-κB signaling pathway can bind to the NF-kb/IkB complex and mask the phosphorylation site of IkB, which inhibits IKK-induced phosphorylation of IkB and activation of NF-κB, thereby inhibiting the metastasis of breast cancer cells (6). This evidence concerns the gene NFKB1 and breast carcinoma.