In the present work, we supposed that the association between PTPRD/PTPRT nonsynonymous mutation and good clinical outcomes of ICBs in NSCLC may partially on account of the up-regulation of JAK1 and STAT1 mRNA expression, which subsequently control the expression of chemokines with potent chemoattractant effect on T cells. This evidence concerns the gene PTPRD and non-small cell lung carcinoma.