Selected glioma genes with high and low UBE2S expression level were separately derived from the TCGA RNA-sequencing database and a heatmap for enrichment scores was generated using the “pheatmap” package in R. IDH1-mutant lower grade glioma had significantly lower levels of UBE2S expression compared with the wild-type (Figure 3A). The gene discussed is IDH1; the disease is central nervous system cancer.