In particular: i) low-CSD melanoma (located on the trunk or extremities and belonging to the superficial spreading or nodular histological subtypes) carries BRAF mutations; ii) melanoma in chronically sun-exposed skin (located in the head and neck region) carries NRAS and/or other RAS mutations; iii) non sun-related melanomas (located on acral sites or mucosae) carry C-KIT mutations or amplifications (62). Here, NRAS is linked to melanoma.