MAPK1 and melanoma: Oncogenic BRAF/mitogen-activated protein kinase kinases (MKK)/ERK signaling in melanoma cells modulates a network of miRNAs, by means of downregulation (let-7i, miR-22, -34a/b, -125a, -132, -211) or upregulation (miR-17-5p, -20a, -92b, -106a/b, -221/222) of miRNA expression (99).