In families without mutations in CDKN2A and CDK4 genes, the use of NGS methodologies has allowed the identification of rare germline mutations in a few novel melanoma susceptibility genes, namely BRCA1 Associated Protein 1 (BAP1), TERT, Protection of Telomeres 1 (POT1), ACD Shelterin Complex Subunit and Telomerase Recruitment Factor (ACD), TERF2 Interacting Protein (TERF2IP) (high risk genes) and MC1R, MITF (low to moderate risk genes). This evidence concerns the gene TERT and melanoma.