IL2 and melanoma: By functional interpretation analysis of 6296 genes differentially expressed between BRAF-mutant samples with high or low BRAF mRNA expression, Interleukin 2 (IL-2) and Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling emerged among the deregulated pathways, supporting the immunoregulatory role of BRAF in melanoma (21).