Depend on molecular and histological evidences, BC could be classified into BC expressing hormone receptor (estrogen receptor (ER+) or progesterone receptor (PR+)), BC expressing human epidermal receptor 2 (HER2+) and triple-negative breast cancer (TNBC) (ER−, PR−, HER2−) (2, 3). Here, ESR1 is linked to triple-negative breast carcinoma.