Through the single-factor Cox regression analysis method, we found that the following clinical indicators are the key factors for the early recurrence and poor prognosis of liver cancer: Tumor size > 5 cm (P =0.049), BCLC stage (P = 0.024), AFP > 400 μg/L (P = 0.002), PIVKA > 400 μg/L (P = 0.039), Nanog>6.7 (P = 0.005), and HBV-DNA >100 (P = 0.017). The gene discussed is NANOG; the disease is neoplasm.