Qu, Chu & Wang (2017) demonstrated that miR-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1. Zhang et al. (2019) discovered that DOC2B promoted insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle. Importantly, we found that circRNA hsa_circ_0042409 and KLC1 mRNA were significantly increased while hsa-miR-195-5p was significantly decreased in male osteoporosis patients by whole transcriptome sequencing and further validated by qPCR. The gene discussed is INS; the disease is osteosarcoma.