RUNX2 and osteoporosis: Wei et al. (2012) found that miR-34s inhibit osteoblast proliferation and differentiation in mice by targeting SATB2. Xia et al. (2016) also discovered that miR-31-5p and miR-424-5p were downregulated in cartilage-derived mesenchymal stem cells (CMSCs) from the degraded cartilage. Moreover, Yin et al. (2018) reported previously that circRUNX2 regulated RUNX2 to prevent osteoporosis via hsa-miR-203.