CREB1 and brain infarction: Ko et al. (2018) demonstrated that Paeoniflorin decreases neurological deficit score and enhances motor function. Tang et al. (2010b) suggests that both pre-treatment and post-treatment with PF reduced the ratio of cerebral infarction area; pre-treatment with Paeoniflorin also reduced the neurological deficit score. Zhang et al. (2017b) indicates that the protective effect of Paeoniflorin on cerebral ischemia reperfusion injury is possible through regulating the Ca2+/CaMKII/CREB signaling pathway.