MAPK8 and Stroke: Given the regulatory role of Paeoniflorin in Jun N-terminal kinase (JNK) signaling in many diseases (Liu et al., 2019; Wu et al., 2019a; Zhang et al., 2017a) and the effect of JNK on regulating inflammatory response (Chen et al., 2018), we next investigated whether Paeoniflorin repressed JNK signaling activation in rat stroke model.