In 2013, Lee et al. found that in a study of 345 breast cancer patients, estrogen (ER) and progesterone (PgR) positivity and tumor size were inversely associated with pCR; HER2+ and triple-negative tumors were more likely to achieve pCR than hormone receptor-positive and HER2-negative cancers [10]. This evidence concerns the gene ESR1 and neoplasm.