More importantly, the levels of VCAM-1, ICAM-1, and E-selectin, which are three major markers of endothelial dysfunction [9], were remarkably decreased in obese children and adolescents after a 12-week exercise training, which indicated the protective effects of exercise on endothelial dysfunction in obese children and adolescents. The gene discussed is VCAM1; the disease is endothelial dysfunction.