As asthma associated with CRSwNP is highly eosinophilic, anti-leukotriene (Montelukast), anti-IgE (Omalizumab) and anti IL-5 (Mepolizumab and reslizumab) treatments have shown promising results for both asthma and polyposis-sinus [18,19]. This evidence concerns the gene IGHE and asthma.