S100A1 and glioblastoma: For example, the mesenchymal subtype, known as the most aggressive GBM, showed overexpression of MGMT and VIM, and the repression of EGFR, H3F3A, OLIG2, S100A and TP53. On the other hand, while overexpression of EGFR, NES, VIM and TP53 was characteristic of the proliferative or classical subtype, concomitant overexpression of MKI67 and OLIG2 could be more favourable prognosis owing to their association with the less aggressive proneural subtype.