ATRX encodes an adaptor protein that contributes to the Methyl-CpG binding protein 2 (MeCP2)-mediated pericentric heterochromatin organization, which is very important for neural differentiation [22]; thus, downregulation of this gene might be expected in cells of a less differentiated subtype with more stemness such as the mesenchymal GBM subtype. Here, MECP2 is linked to glioblastoma.