We searched the literature over the last 15 years and found 60 clinical reports of 73 clinical cases in which patient tumour biopsy or fluid sample underwent the analysis of a combination of biomarkers which mainly consisted in IDH1, GFAP, MKi67 and MGMT coupled in sets with more than two and up to 11 additional markers per sample for diagnosis. The gene discussed is IDH1; the disease is neoplasm.