SMAD3 and pancreatic neoplasm: Driver genes of tumorigenesis shared between GMB and the hsa:0513 pancreatic cancer pathway are BRAF, EGFR, SMAD3, PIK3CA, TP53, IDH1, TERT, VIM, ATRX and GFAP. Owing to their high proliferative condition, cancer cells have an increased demand for nutrients.