Several potent small molecule UDG inhibitors with IC50 values between 1.1 to 315 μM have been identified by screening linked libraries using 6-formyl uracil as the substrate fragment.13,16,17 However, none of these have undergone further in-depth disease application research, such as the treatment of drug-resistant cancers, including in combination therapy with clinical drugs. The gene discussed is UNG; the disease is cancer.