HMGB1 and ATP release and calreticulin relocation are key components of this pathway, examples of DAMPs which can be screened to detect ICD.214 Oxaliplatin (Pt3) induces ICD detectable by HMGB1 in patient serum and released from cell lines.196,197 NKP1339 (Ru9) induces ICD with calreticulin relocation and HMGB1 release.195 Importantly, the anticancer activity of oxaliplatin and related PtIV complexes in in vivo models often requires an intact immune system.215 Effectively some metal complexes may act as vaccines against cancer recurrence. The gene discussed is CALR; the disease is cancer.