The organo-IrIII complex ZL109 (Ir7†) stimulates cell cycle arrest in A2780 ovarian cancer cells after 24 h exposure either during replication (S-phase) or after the doubling of DNA content (G2-phase).149 Organo-OsII complex FY26 (Os4) inhibits cell cycle progression at the G1-phase, prior to DNA replication, consistent with its proposed redox modulation (ROS) and not a DNA-focussed MoA.220 ROS can also cause DNA damage indirectly. This evidence concerns the gene CTDSP2 and ovarian carcinoma.