ICD is associated with the release of damage-associated molecular patterns that are beneficial for antigen uptake and subsequent immune system activation.100,101 For instance, Qian and coworkers102 constructed multifunctional nanodrugs with the abilities of tumor-targeting, penetration enhancement, targeted drug release behavior, and immunomodulation mediated by checkpointed blockade (PD-1/PD-L1). Here, CD274 is linked to neoplasm.