Analogously, Guo et al. also constructed a Fe3O4@PDA@mSiO2 core–shell material for targeted PTT (Fig. 7a).100 In this study, tumor-identified Tf and mitochondria-targeted TPP were anchored on the surface of Fe3O4@PDA@mSiO2 materials to enhance their transport to tumor subcellular organelles. The gene discussed is TNS3; the disease is neoplasm.